Synthesis, Crystal Structure and DNA Interaction of N-(Benzimidazol-2-ylmethyl)-5-chlorosalicylideneimine

The title compound, N-(benzimidazol-2-ylmethyl)-5-chlorosalicylideneimine, has been synthesized and characterized by X-ray single-crystal diffraction. It crystallizes in the monoclinic system, space group P21/n, with a = 8.3765(2), b = 18.1398(4), c = 9.4764(3) A, β = 112.141(2)°, V= 1333.74(6) A3, Mr = 285.73, Z = 4, Dc = 1.423 g/cm3, F(000) = 592, μ= 0.285 mm-1, the final R = 0.0538 and wR = 0.1456 for 1917 observed reflections with I > 2σ(Ⅰ). The fluorescence quenching of the title compound by DNA with Stern-Volmer constant of 2.8×104 M1 indicates that it binds to double-stranded DNA in a partial intercalation mode.

作 者： CHENG Jian-Ping LIN Qiu-Yue ZHU Wen-Zhong WANG Yun-Yun XIAN Hui-Duo   作者單位： CHENG Jian-Ping,LIN Qiu-Yue,ZHU Wen-Zhong(Zhejiang Key Laboratory for Reaction Chemistry on Solid Surfaces,Zhejiang Normal University,Jinhua 321004,China;College of Chemical and Life Science,Zhejiang Normal University,Jinhua 321004,China)

WANG Yun-Yun,XIAN Hui-Duo(Zhejiang Key Laboratory for Reaction Chemistry on Solid Surfaces,Zhejiang Normal University,Jinhua 321004,China) 

刊 名： 結構化學  ISTIC SCI PKU 英文刊名： CHINESE JOURNAL OF STRUCTURAL CHEMISTRY  年，卷(期)： 2009 28(2)  分類號： O6  關鍵詞： crystal structure   2-aminomethylbenzimidazole   5-chlorosalicylaldehyde   DNA  

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